Background and Objectives As pediatric COVID-19 vaccine eligibility expands, understanding predictors of vaccine intent is critical to effectively address parental concerns. Objectives included: 1) Evaluate maternal COVID-19 vaccine intent for child(ren) and associated predictors of stated intent; 2) Describe attitudes related to hypothetical vaccination policies; 3) Summarize themes associated with intention to vaccinate child(ren) for COVID-19. Methods Mothers enrolled in Heath eMoms, a longitudinal survey project, were recruited for this electronic COVID-19 survey. Chi-square analysis was used to compare proportions of respondent characteristics based on vaccination intent. Population survey logistic regression was used for multivariable modeling to assess the independent association between vaccine intent and demographics. Results The response rate was 65.3% (n= 1884); 44.2% would choose vaccination, 20.3% would not choose vaccination, and 35.5% are unsure whether to have their child(ren) vaccinated for COVID-19. Black mothers (AOR 0.26, 95% CI 0.13, 0.54), respondents with less than high school education (AOR 0.26, 95% 0.12, 0.56) and those in rural areas (AOR 0.28, 95% CI 0.16, 0.48) were less likely to choose vaccination. Commonly cited reasons for vaccine hesitancy include belief the vaccine will not have been tested enough, is not safe and worry regarding side effects. Conclusions Over 50% of respondents do not intend or are unsure about their intent to vaccinate their child(ren) for COVID-19 with variability noted by demographics. Opportunities exist for perinatal and pediatric providers to educate pregnant people, parents, and caregivers with a focus on addressing concerns regarding vaccine safety and efficacy.

Penelitian ini bertujuan untuk mendeskripsikan strategi pendidik anak usia dini dalam melaksanakan tugas-tugasnya pada masa pandemi coronavirus disease atau COVID-19 Peneliti menggunakan pendekatan kualitatif dengan metode studi kasus untuk memperoleh pemahaman tentang strategi pendidik anak usia dini dalam mengembangkan kemampuan berfikir logis pada anak Teknik pengumpulan data yang digunakan adalah wawancara dan dokumentasi Data yang dikumpulkan selanjutnya dianalisis dengan menggunakan interaktif model dengan langkah-langkah analisis data yaitu reduksi data, penyajian data, penarikan kesimpulan dan verifikasi Hasil penelitian menunjukkan bahwa pertama, ada perubahan strategi pelaksanaan tugas guru PAUD yaitu sebagai perencana dan penilaian hasil pembelajaran sedangkan untuk tugas pelaksana pembelajaran guru PAUD dibantu oleh pendidik di rumah (orang tua) peserta didik;kedua, strategi pendidik PAUD di rumah dalam mengembangkan kemampuan berfikir logis anak yaitu anak diajak untuk memahami mengapa sekolah di rumah, mengapa keluar rumah harus menggunakan masker, kenapa tidak bisa bermain di luar rumah menggunakan metode dialog (percapakan /diskusi) dan keteladanan

Background: In the last time, many papers about SARS-CoV-2 have been published in the world. However, data from latinamerican patients is still scarce. In order to assess the impact of SARS-CoV-2 infection in patients with rheumatic diseases in our country and contribute to the global knowledge about the effect of immunosuppressive therapies in this group, the Argentine Society of Rheumatology has developed the National Registry of Patients with Rheumatic Diseases and COVID-19 (SAR-COVID). Objectives: The aim of this study was to evaluate clinical characteristics and outcomes of SARS-CoV-2 infection in patients with rheumatic diseases, treated or not with immunomodulators and/or immunosuppressants. Methods: SAR-COVID is a national, multicenter, prospective and observational registry, in which patients, 18 years of age, with a diagnosis of a rheumatic disease who had SARS-CoV-2 infection (PCR or positive serology) are consecutively included between August 13, 2020 and January 17, 2021. Sociodemographic data, comorbidities, underlying rheumatic disease and treatment, clinical characteristics, complications, laboratory and treatment of the SARS-CoV-2 infection were recorded. Hospitalization, mechanical ventilation requirements and death were assessed to evaluate COVID-19 outcome. Statistical analysis: Descriptive analysis. Chi2 or Fischer test and T test or Mann-Whitney U test or ANOVA, as appropriate. Multiple logistic regression. Results: A total of 525 patients were included, 80.4% were female, with a median age of 52 years (IQR 40-62). Comorbidities were reported in half of them (53.3%). The most frequent rheumatological diseases were rheumatoid arthritis (40.4%) and systemic lupus erythematosus (14.9%). At the time of the infection, most of them were in remission or in minimal/low disease activity (68.2%) and 72.9% were receiving immunosuppressive or immunomodulatory treatment. Symptoms were present in 96% of the patients, the most frequent being fever (56.2%), cough (46.7%) and headache (39.2%). During infection, 35.1% received some pharmacological treatment, dexamethasone (20%) the most frequently used. One third (35.1%) of the patients were hospitalized, 11.6% were admitted to the ICU, 10.1% needed mechanical ventilation and 6.9% died due to COVID-19. Complications were reported in 12.4%, being acute respiratory distress syndrome the most prevalent (8.8%). Patients over 65 years of age were more frequently hospitalized, admitted to the ICU, needed mechanical ventilation and died due to COVID-19 (50% vs 31.4%, 22% vs 9%, 16.3% vs 5.2%, 14% vs 5%, respectively;p<0.001 in all cases). Similar results were seen in patients with vasculitis (57.7% vs 33.9%, 46.2 vs 9.8%, 34.6% vs 6 %;30.8% vs 5.6%, respectively;p< 0.001 in all cases) and those with moderate/high disease activity (55.7% vs 26.5%, 21.3 vs 7.8%, 17.2% vs 4.2 %;17.2% vs 4.2 %, respectively;p< 0.001 in all cases). Patients with APS were more frequently admitted to the ICU (29.4% vs 11%, p= 0.037). The presence of comorbidities was associated with higher hospitalization (46% vs 22.6%, p<0.001), admission to the ICU (17.2% vs 5.9%, p<0.001) and mechanical ventilation (10.2% vs 4.6%, p= 0.028). Immunosuppressive treatment was not associated with worse outcomes. Conclusion: In this cohort of patients with a wide distribution of rheumatic diseases, we have found clinical characteristics similar to those reported by other international cohorts. Compared with national data, the mortality reported in these patients is higher. However, it should be noted that these are early data collected during isolation and that there may be an underreporting of asymptomatic patients or with mild symptoms who do not attend the rheumatologist. Older patients, those with comorbidities, with vasculitis and with higher disease activity showed poor COVID-19 outcomes.

The move came after a U turn by the Medicines and Healthcare Products Regulatory Agency, which had initially deemed the Innova test not fit for use among asymptomatic people in the community but changed its guidance for this purpose on 23 December 1 Plans to test communities for the virus were detailed in the governments Moonshot documents, revealed by The BMJ in September 2 Iain Buchan, executive dean and chair in public health and clinical informatics at the University of Liverpool, who led the analysis of a pilot of community testing in the city,4 said that the Innova test had become a valuable tool within a wider public health intervention that was popular with the public [ ]Christina Pagel, professor of operational research at University College Member and a member of the Independent Scientific and Advisory Group of Experts, said that regular repeated testing reduced the chances of a false negative result and could play an important role in reducing transmission among people who cannot work at home In the Liverpool pilot, they said, the test missed infection in 60% of people, and most worryingly it missed 30% of those in people with very high viral loads, who are at the highest risk of spreading the virus to others 3 False reassurance Writing in BMJ Opinion, Jon Deeks, who leads the Cochrane Collaborations covid-19 test evaluation activities, Angela Raffle, a health screening expert from the University of Bristol, and Mike Gill, a former member of the UK National Screening Committee, said that the government was misleading the public about the performance of the Innova test 4 Results from government studies have been selectively reported and some have not been reported at all

The Coronavirus Disease-2019 (COVID-19) pandemic has brought catastrophic impact on the world since the beginning of December 2019. Extra precautionary measures against COVID-19 during and after delivery are pivotal to ensure the safety of the baby and health care workers. Based on current literature, it is recommended that delivery decisions be discussed between obstetricians and neonatologists prior to delivery, and designated negative pressure delivery rooms should be arranged for COVID person under investigation (PUI). During delivery, a minimal number of experienced staff attending delivery should don personal protective equipment (PPE) and follow the neonatal resuscitation program (NRP). Positive pressure ventilation is best used in a negative pressure room if available. At-risk babies should be transported in an isolette, and tested for COVID-19 in a negative pressure room soon after bathing. Skin-to-skin contact and breast milk feed should continue under certain circumstances. Although newborns with COVID-19 infections often present with symptoms that mimic sepsis and one third of affected patients may demand some form of respiratory support, short-term prognoses are favorable and most recover within two weeks of symptoms onset. In this article, we will further elaborate on topics covering timing and mode of delivery, antenatal steroid, vertical transmission, delivery room management, airway management, transport, testing and isolation after birth, skin-to-skin contact, breast milk feeding, clinical features, outcomes, and discharge plans. In addition, we also share our experiences of encountering neonates born of suspected COVID-19 positive mothers.

In this work we use simple mathematical models to study the impact of vaccination against COVID-19 in Portugal. First, we fit a SEIR type model without vaccination to the Portuguese data on confirmed cases of COVID-19 by the date of symptom onset, from the beginning of the epidemic until the 23rd January of 2021, to estimate changes in the transmission intensity. Then, by including vaccination in the model we develop different scenarios for the fade-out of the non pharmacological intervention (NPIs) as vaccine coverage increases in the population according to Portuguese vaccination goals. We include a feedback function to mimic the implementation and relaxation of NPIs, according to some disease incidence thresholds defined by the Portuguese health authorities.

Objective: To reflect on the impacts of COVID-19 in northern Italy, the European epicenter of the pandemic Development: The approach developed since the advent of the disease, its arrival in Italy and its repercussions, not only in the health field, but also in the human relationships and the social environment The epidemic has been impacting the lives of health professionals and has mobilized advances in research around the world Final considerations: It is considered that coping with the disease in the country evidenced the role of Nursing as a care profession and that it will allow for a new thinking about Nursing teaching, care, and research ? 2020, Universidade Federal do Parana All rights reserved

Abstract Introduction: Social distancing measures (SDMs) protect public health from the outbreak of coronavirus disease 2019 (COVID-19). However, the impact of SDMs has been inconsistent and unclear. This study aims to assess the effects of SDMs (e.g. isolation, quarantine) for reducing the transmission of COVID-19. Methods and analysis: We will conduct a systematic review meta-analysis research of both randomised controlled trials and non-randomised controlled trials. We will search MEDLINE, EMBASE, Allied & Complementary Medicine, COVID-19 Research and WHO database on COVID-19 for primary studies assessing the enablers and barriers associated with SDMs, and will be reported in accordance with PRISMA statement. The PRISMA-P checklist will be used while preparing this protocol. We will use Joanna Briggs Institute guidelines (JBI Critical Appraisal Checklists) to assess the methodological qualities and synthesised performing thematic analysis. Two reviewers will independently screen the papers and extracted data. If sufficient data are available, the random-effects model for meta-analysis will be performed to measure the effect size of SDMs or the strengths of relationships. To assess the heterogeneity of effects, I2 together with the observed effects (Q-value, with degrees of freedom) will be used to provide the true effects in the analysis. Ethics and dissemination: Ethics approval and consent will not be required for this systematic review of the literature as it does not involve human participation. We will be able to disseminate the study findings using the following strategies: we will be publishing at least one paper in peer-reviewed journals, and an abstract will be presented at suitable national/international conferences or workshops. We will also share important information with public health authorities as well as with the World Health Organization.

Introduction De par leur impact pidmiologique court et long termes, aussi bien lchelle individuelle que collective, la COVID-19 et la tuberculose (TBC) sont deux maladies infectieuses redoutables, tropismes respiratoire privilgi. Des facteurs de risque, clairement identifis, influenceraient le risque de survenue de linfection, le dveloppement de la maladie ou son volution dfavorable. Dans ce sens quel r?le jouerait la tuberculose dans le risque de survenue de formes graves de COVID-19 ? Nous nous proposons de dterminer la relation entre la tuberculose maladie et la forme grave de COVID-19 chez les patients pris en charge au niveau du service de pneumologie Annaba, Algrie. Mthodes Enqute tlphonique ralise auprs de lensemble des patients pris en charge pour tuberculose pulmonaire (TP) et/ou extrapulmonaire (TEP), de janvier 2019 juillet 2021. Rsultats 547 patients ont t colligs : 228 cas en 2019, 190 en 2020 et 129 cas en 2021 (janvierCjuillet). Pour exemple, sur les 228 personnes prises en charge pour tuberculose en 2019, 74 personnes ont pu tre contacts (5 dcds, 9 perdus de vue et 140 ayant chang doprateur tlphonique). Lage moyen des patients tait de 37, 33 ans (8 avaient moins de 16 ans) avec une prdominance fminine (43 cas). 3 patients avaient dj t traits pour tuberculose, 15 avaient des comorbidits. Latteinte extrapulmonaire taient plus rpondue (47 cas). Sur les 74 cas contacts, uniquement 13 ont rcemment t vaccins contre le SARS-COV 2. Une infection COVID-19 a t note chez 23 patients, documente chez 10 dentre eux dont un aurait prsent une forme grave ayant ncessit une hospitalisation de 21jours. Lintgralit des rsultats de notre travail (2019, 2020 et 2021) vous seront prsents ultrieurement. Conclusion Dans un pays prvalence intermdiaire de tuberculose, en ces temps de pandmie o la COVID-19 constitue une menace sanitaire mondiale, une rflexion approfondie doit tre mene afin de statuer sur le r?le de la maladie tuberculeuse dans la survenue des formes graves de COVID-19 : facteur pourvoyeur, protecteur ou indiffrent.

Epiglottitis is an uncommon, potentially fatal infection of the epiglottis that can lead to complete upper airway obstruction. Isolated pathogens are usually nasopharyngeal bacteria, most commonly Haemophilus influenzae type b (Hib). While the incidence of epiglottitis has diminished significantly over the years due to widespread vaccination against Hib, the proportion of epiglottitis caused by other pathogens has increased. In this report, we introduce an unseen presentation of acute epiglottitis associated with severe acute respiratory distress syndrome--coronavirus2 (SARS-CoV-2), who presented to the emergency department with throat pain and odynophagia that quickly resulted in respiratory distress. Clinicians should be aware of airway edema's concomitant presence in patients with acute epiglottitis and COVID-19 and maintain a low threshold for intubation. The rapidly progressive nature of COVID-19 and its complications may preclude intubation later on in the patient's clinical course, potentially necessitating an emergent surgical airway.

BACKGROUND: High stress prenatally contributes to poor maternal and infant well-being. The coronavirus disease 2019 (COVID-19) pandemic has created substantial stress for pregnant women. PURPOSE: To understand whether stress experienced by women pregnant at the beginning of the pandemic was associated with a greater prevalence of adverse perinatal outcomes. METHODS: Pregnant women across the USA aged &#8805;18 years old enrolled in a prospective cohort study during the pandemic onset (T1) in April-May 2020. This report focuses on the 1,367 participants who gave birth prior to July-August 2020 (T2). Hierarchical logistic regression models predicted preterm birth, small for gestational age infants, and unplanned operative delivery from T1 stress, sociodemographic, and medical factors. RESULTS: After controlling for sociodemographic and medical factors, preterm birth was predicted by high prenatal maternal stress, delivering an infant small for gestational age was predicted by interpersonal violence and by stress related to being unprepared for birth due to the pandemic, and unplanned cesarean or operative vaginal delivery was predicted by prenatal appointment alterations, experiencing a major stressful life event, and by stress related to being unprepared for birth due to the pandemic. Independent of these associations, African American women were more likely than other groups to deliver preterm. CONCLUSION: Pregnant women who are experiencing high stress during the COVID-19 pandemic are at risk of poorer perinatal outcomes. A longitudinal investigation is critical to determine whether prenatal maternal stress and resulting outcomes have longer-term consequences for the health and well-being of children born in the midst of the current pandemic.

While vaccines and antivirals are now being deployed for the current SARS-CoV-2 pandemic, we require additional antiviral therapeutics to not only effectively combat SARS-CoV-2 and its variants, but also future coronaviruses. All coronaviruses have relatively similar genomes that provide a potential exploitable opening to develop antiviral therapies that will be effective against all coronaviruses. Among the various genes and proteins encoded by all coronaviruses, one particularly druggable or relatively easy-to-drug target is the coronavirus Main Protease (3CLpro or Mpro), an enzyme that is involved in cleaving a long peptide translated by the viral genome into its individual protein components that are then assembled into the virus to enable viral replication in the cell. Inhibiting Mpro with a small-molecule antiviral would effectively stop the ability of the virus to replicate, providing therapeutic benefit. In this study, we have utilized activity-based protein profiling (ABPP)-based chemoproteomic approaches to discover and further optimize cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro. Structure-guided medicinal chemistry and modular synthesis of di- and tri-substituted pyrazolines bearing either chloroacetamide or vinyl sulfonamide cysteine-reactive warheads enabled the expedient exploration of structure-activity relationships (SAR), yielding nanomolar potency inhibitors against Mpro from not only SARS-CoV-2, but across many other coronaviruses. Our studies highlight promising chemical scaffolds that may contribute to future pan-coronavirus inhibitors.

BACKGROUND Social Anxiety Disorder (SAD) is the most common anxiety disorder while remains largely untreated. Disturbed amygdala-frontal network functions are central to the pathophysiology of SAD, marked by hypoactivity of the lateral prefrontal cortex (PFC), and hypersensitivity of the medial PFC and the amygdala. The objective of this study was to determine whether modulation of the dorsolateral and medial PFC activity with a novel intensified stimulation protocol reduces SAD core symptoms, improves treatment-related variables, and reduces attention bias to threatening stimuli. METHODS In this randomized, sham-controlled, double-blind trial, we assessed the efficacy of an intensified stimulation protocol (20 min, twice-daily sessions with 20 min intervals, 5 consecutive days) in two intensities (1 vs 2 mA) compared to sham stimulations. 45 patients with SAD were randomized in three tDCS arms (1-mA, 2-mA, sham). SAD symptoms, treatment-related variables (worries, depressive state, emotion regulation, quality of life), and attention bias to threatening stimuli (dot-probe paradigm) were assessed before and right after the intervention. SAD symptoms were also assessed at 2-month follow-up. RESULTS Both 1-mA and 2-mA protocols significantly reduced fear/avoidance symptoms, worries and improved, emotion regulation and quality of life after the intervention compared to the sham group. Improving effect of the 2-mA protocol on avoidance symptoms, worries and depressive state was significantly larger than the 1-mA group. Only the 2-mA protocol reduced attention bias to threat-related stimuli, the avoidance symptom at follow-up, and depressive states, as compared to the sham group. CONCLUSIONS Modulation of lateral-medial PFC activity with intensified stimulation can improve cognitive control, motivation and emotion networks in SAD and might thereby result in therapeutic effects. These effects can be larger with 2-mA vs 1-mA intensities, though a linear relationship between intensity and efficacy should not be concluded. Our results need replication in larger trials.

We study the evolution of US mortgage credit supply during the COVID-19 pandemic. Although the mortgage market experienced a historic boom in 2020, we show there was also a large and sustained increase in intermediation markups that limited the pass-through of low rates to borrowers. Markups typically rise during periods of peak demand, but this historical relationship explains only part of the large increase during the pandemic. We present evidence that pandemic-related labor market frictions and operational bottlenecks contributed to unusually inelastic credit supply, and that technology-based lenders, likely less constrained by these frictions, gained market share. Rising forbearance and default risk did not significantly affect rates on plain vanilla conforming mortgages, but it did lead to higher spreads on mortgages without government guarantees and loans to the riskiest borrowers. Mortgage-backed securities purchases by the Federal Reserve also supported the flow of credit in the conforming segment.

The outbreak of COVID-19 has caused an exponential increase in mortality rate globally and has dealt a devastating blow to nations all over the world. This unforeseen calamity needs to be tackled and early detection of this disease could help in this regard. Several research studies used Chest X-rays and CT scans to detect the disease, which can be made cost-effective by using cough samples. These systems can further be refined by using multiple health parameters to provide more accurate results. In this view, this paper proposes a constructive way for the early detection of COVID-19 by considering cough samples and clinical data (Saturation of Peripheral Oxygen (SpO2) level, body temperature, heart rate, and symptoms). The dataset was collected by using a Raspberry Pi and an online questionnaire. In this paper, we put forward two approaches being Manual feature extraction and Mixed data neural networks (Multi-layer Perceptron and Convolutional Neural Networks) for efficiently handling the problem. To help the user access the system more comfortably, a mobile application was developed. The Mixed data neural networks yielded the best performance with an Area Under the Curve (AUC) score of 0.94 and an accuracy of 0.85. ? 2021 IEEE.

Social isolation of older adults was identified as a key public health issue prior to the onset of COVID-19. The current crisis raises serious questions about how societies are organized and function in relation to aging populations. Drawing on resources in critical gerontology on precarious aging (Butler, 2009; Grenier & Phillipson, 2018) and an intersectional approach (Crenshaw, University of Chicago Legal Forum, 1(8), 139C167, 1989) that recognizes aging as an axis of oppression, we will (1) outline how this pandemic provides opportunities for candid dialogue about systemic institutional failures within leisure and social services sectors as they relate to older adults, taking important intersections of race, class, gender and ability into account; (2) examine how leisure and the arts have been positioned in response to social isolation of older people during a pandemic and (3) explore the risks of further marginalization inherent in these activities even as they are potentially crucial and transformative social lifelines for older adults. We call the further marginalization of older adults already precariously positioned pandemic precarity..

The direct threat posed by the 2019 novel coronavirus (COVID-19), uncertainty surrounding best safety practices, and secondary consequences of the virus have led to widespread stress and declining mental health across communities and individuals. These stresses may impact parenting behaviors, potentially leading to negative consequences for children. Controlling parenting behaviors increase in the face of perceived environmental threat and are associated with adverse mental health outcomes for children; however, determinants of parenting behaviors have not been investigated during the COVID-19 pandemic. The current study prospectively evaluated parenting behaviors during the pandemic (N=87). Results indicated that all negative affect emotions investigated were positively associated with controlling parenting behaviors. However, only COVID-related fear predicted changes in controlling parenting behaviors across timepoints. Specifically, although controlling parenting behaviors decreased in the overall sample from time 1 to time 2, higher COVID-related fear scores at time 1 predicted maintenance of high levels of controlling parenting behaviors at time 2. Additionally, this effect was specific to controlling, as opposed to more adaptive, parenting behaviors. Future studies should investigate the association between parents' COVID-related fear, controlling parenting behaviors, and adverse mental health outcomes for children in the context of the COVID-19 pandemic.

This is a narrative medicine essay that combines my reflections about COVID-19, racism in medicine, working in an inner-city health center, and reopening after the first wave of the pandemic in Massachusetts (PsycInfo Database Record (c) 2021 APA, all rights reserved) ? 2020 American Psychological Association American Psychological Association

The current paradigm of robot-assisted surgeries (RASs) depends entirely on an individual surgeon's manual capability. Autonomous robotic surgery-removing the surgeon's hands-promises enhanced efficacy, safety, and improved access to optimized surgical techniques. Surgeries involving soft tissue have not been performed autonomously because of technological limitations, including lack of vision systems that can distinguish and track the target tissues in dynamic surgical environments and lack of intelligent algorithms that can execute complex surgical tasks. We demonstrate in vivo supervised autonomous soft tissue surgery in an open surgical setting, enabled by a plenoptic three-dimensional and near-infrared fluorescent (NIRF) imaging system and an autonomous suturing algorithm. Inspired by the best human surgical practices, a computer program generates a plan to complete complex surgical tasks on deformable soft tissue, such as suturing and intestinal anastomosis. We compared metrics of anastomosis-including the consistency of suturing informed by the average suture spacing, the pressure at which the anastomosis leaked, the number of mistakes that required removing the needle from the tissue, completion time, and lumen reduction in intestinal anastomoses-between our supervised autonomous system, manual laparoscopic surgery, and clinically used RAS approaches. Despite dynamic scene changes and tissue movement during surgery, we demonstrate that the outcome of supervised autonomous procedures is superior to surgery performed by expert surgeons and RAS techniques in ex vivo porcine tissues and in living pigs. These results demonstrate the potential for autonomous robots to improve the efficacy, consistency, functional outcome, and accessibility of surgical techniques.

Objectives: Real-life overview of bladder cancer (BC) surgical management in Italy during the first month of COVID-19 pandemic (March 2020) with head to head comparison of the data from March 2019, considered usual activity period. The aim is to confront performance of Academic Centers (AC) vs Non Academic Centers (NAC) as well as non-COVID Centers (nCC) and COVID Centers (CC). Patients and methods: During April 2020, an e-mail survey was sent to 32 Sections of Urology across Italy. It contained 14 multiple-choice questions focused on activities during March 2019 and March 2020. Statistical analysis was performed using IBM SPSS Statistics (v26) software. Results: 28 centers answered to survey. AC and NAC showed statistically significant differences (chi-square test p<0.05) about number of physicians assigned to Covid wards (p=0.001), Trans-Urethral Resection of Bladder Tumour (TURBT) (p=0.046) and cystectomies (p=0.037) performed in March 2020 (p=0.037). In 2020, AC performed more surgical procedures compared to NAC. In 2019, AC had more procedures per Operating Block (OB) (p=0.015) and greater number of emergent Trans-Urethral Resections (TUR) (p=0.014), while NAC had more TURBTs. CC had more patients (pts) both evaluated for gross hematuria (p=0.017) and requiring haemostatic Trans-Urethral Resection (hTUR) in 2019. In 2020 nCC had more surgeries per OB (p=0.001), TURBTs (p=0.030) and cystectomies (p=0.034) than CC. Conclusion: The COVID-19 pandemic represents an important challenge for cancer centers, in the context of an extremely dynamic clinical and political situation which requires maximum flexibility to be appropriately managed.