[Image: see text] The COVID-19 outbreak in China led to dramatic changes in human activities resulting from the sudden infection prevention and control measures. Here, we use ground-level observations and model simulations to examine the nationwide spatialCtemporal variations of six air pollutants before and after the initiation of First-Level Public Health Emergency Response. The level of ambient NO(2) declined significantly, and in most cities, the decline was dominated by reduced emissions. Meanwhile, the level of O(3) increased significantly during this period, and the nonmeteorological factors explained the increase. For the other air pollutants (PM(2.5), SO(2), and CO), the observed declines on the national scale were obviously affected by the meteorological conditions. In Wuhan, significant declines were found for air pollutants except O(3) and emissions dominated the changes, while in Beijing during the same period, only the level of NO(2) significantly declined. This study clearly shows that the meteorological changes contributed substantially to the observed changes in most air pollutants, and this must be considered in evaluating the impacts of pollutant source changes on air quality during the specific event and in assessing source-oriented risks.

The olfactory effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that causes the novel coronavirus disease 2019 (COVID-19), have been well documented among other neurologic manifestations. Although olfaction recovers within a few days in most cases, some patients develop a more protracted course of olfactory impairment, lasting for several weeks. To date, there are no reports on Magnetic Resonance Imaging (MRI) findings in patients with persistent anosmia or hyposmia due to COVID-19. Hence, we performed a pilot case control study on MRI findings in recovered COVID-19 patients with protracted olfactory dysfunction.

Abstract The role of aquatic plants in treating wastewater contaminated with inorganic and organic pollutants is well established. Recent studies have shown that aquatic plants possess potential to remove pathogens from wastewater. High removal (90%) of pathogenic microbes such as Enterococci, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Clostridium perfringens, Staphylococcus aureus, and Salmonella have been achieved using aquatic plant species viz. Typha latifolia, Cyperus papyrus, Cyperus alternifolius, Phragmites mauritianus, Pistia stratiotes, Lemna paucicostata, Spirodela polyrhiza, Eichhornia crassipes. Pathogen removal by aquatic plants mainly occurs because of toxicity exerted by exudates produced by them or attachment of pathogens to plant roots followed by filtration. Constructed wetlands have proved very efficient in treating pathogen-contaminated water. More studies are required to find out the exact mechanism of pathogen removal by these plants so that their role in phytoremediation technologies can be emphasized.

BACKGROUND: The epidemiologic and clinical characteristics of heart transplant (HTx) recipients during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic remains unclear. We studied the characteristics of HTx recipients from December 20, 2019, to February 25, 2020, in an effort to understand their risk and outcomes. METHODS: All accessible HTx recipients were included in this single-center retrospective study. We collected information on the recipients using a web-based questionnaire as well as the hospital database. RESULTS: We followed 87 HTx recipients (72.4% were men, and the average age was 51 years). A total of 79 recipients resided in Hubei, and 57 recipients had a Wuhan-related history of travel or contact. Most took precautionary measures while in contact with suspicious crowds, and 96.6% of the families and communities undertook prevention and quarantine procedures. Four upper airway infections were reported, and 3 of them tested negative for SARS-CoV-2 (the fourth recovered and was not tested). All cases were mild and successfully recovered after proper treatment. Laboratory results of 47 HTx cases within the last 2 months were extracted. Of these, 21.3% of recipients had pre-existing lymphopenia, and 87.2% of recipients had a therapeutic concentration of tacrolimus (5-12 ng/ml). Liver and kidney insufficiency was seen in 5 and 6 recipients, respectively. CONCLUSION: HTx recipients who practiced appropriate prevention measures had a low rate of infection with SARS-CoV-2 and transition to the associated disease COVID-19. These early data will require confirmation as the pandemic establishes around the world.

Invasive pulmonary aspergillosis (IPA) may complicate severe COVID-19 patients The incidence, although is not well confirmed, varies (20-35%) and the already recognized host factors for IPA in immunosuppressed patients are not identified in non-immunocompromised patients with COVID-19 associated pulmonary aspergillosis (CAPA) Additionally, clinical characteristics and radiological findings are not specific Given the probable high burden of the co-infection, a screening diagnostic work-up, including serum and BAL galactomannan measurement, fungal cultures of upper and lower respiratory tract samples are considered mandatory in all mechanically ventilated patients with COVID-19

OBJECTIVE: The main objective is to investigate the effect of Yifei-Huoxue decoction combined with tiotropium on the inflammatory cytokine levels, pulmonary function, and quality of life in patients with chronic obstructive pulmonary disease (COPD). METHODS: Ninety-eight COPD patients who were treated in our hospital from January 2021 to January 2022 were selected as the research objects, and they were divided into reference group (routine treatment) and study group (Yifei-Huoxue decoction combined with tiotropium), with 49 cases in each group. The patients' clinical indexes were compared between the two groups, and the clinical efficacy in the two groups was analyzed. RESULTS: Compared with the reference group, the study group had remarkably lower inflammatory cytokine levels (including tumor necrosis factor- (TNF-), C-reactive protein (CRP), and interleukin-6 (IL-6)) after treatment (P > 0.05). In terms of the patients' pulmonary function indexes after treatment, the study group achieved lower forced vital capacity (FVC), forced expiratory volume in 1s (FEV1), and FEV1/FVC levels compared with the reference group (P < 0.05). Both groups had a lower erythrocyte sedimentation rate (ESR) after treatment compared with that before treatment. However, the intergroup difference in the ESRs after treatment was remarkable, and the study group had a much lower ESR compared with the reference group (P < 0.05). Compared with the reference group, the study group achieved much higher 36-item short form health survey (SF-36) scores in dimensions of general health, physical functioning, social functioning, and mental health after treatment (P < 0.05). CONCLUSION: Yifei-Huoxue decoction combined with tiotropium not only enhances the COPD patients' pulmonary function but also decreases their inflammatory levels. Therefore, this treatment is conducive to promoting the COPD patients' recovery and exerts positive effect on improving their quality of life.

Outcomes 1. Identify how resiliency contributes to chronic illnesses such as SCD 2. Discuss technique for assessing child resiliency (ie, parental assessment) 3. Identify potential for interventions to improve resiliency and associated markers of disease management Original Research Background Families with a child with sickle cell disease (SCD) have unique stressors and challenges. A key adaptive response to these is resiliency. Previous studies have focused on parental resiliency and psychosocial factors that affect the child's health. None have measured the resiliency of children with SCD or its relationship with their parent's resiliency or SCD complications. Research Objectives Thegoal of this study was to examine the relationship between child's and parent's resiliency and perceived stress. Our primary outcome was the association between resiliency scores and SCD specific stressors including acute access to healthcare and previous stroke or stem cell transplant. The impact of the COVID pandemic and sources of stress were surveyed. Methods Connor-Davidson Resiliency Scale (CD-RISC), Perceived Stress Scale (PSS-10), PROMIS 8a Depression Scale, and PROMIS 8a Anxiety Scale data were collected from children >12 years old with SCD and their parents (n = 55). Parents scored their child with a modified CD-RISC. Frequency of hospitalization, acute clinic visits, and emergency room visits over previous year and history of stroke and stem cell transplant were ed from medical record. Sources of stress and SCD management during pandemic versus before were assessed with Likert scale. Results Parentassessment of their child's resiliency was accurate (p < 0.0001). Increased hospitalization was associated with lower child CD-RISC score (p = 0.0386). No relationship between child and parent CD-RISC or PSS-10 scores was observed. Both reported no difference in SCD management during the COVID pandemic. However, concern about getting sick from COVID and concern about SCD were the most common stressors. Conclusion SCD resiliency may affect how often children need hospitalization. The COVID pandemic did not affect parent and child assessment of SCD management, despite being a common stressor. Implications for Research, Policy, or Practice Interventions to improve resiliency of children with SCD may help reduce the frequency of hospitalizations.

Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to the beta coronavirus subfamily and causes severe morbidity and mortality in humans especially when infected patients have underlying diseases such chronic obstructive pulmonary disease (COPD). Previously, we demonstrated that MERS-CoV-encoded ORF8b strongly inhibits MDA5- and RIG-I-mediated induction of the interferon beta (IFN-) promoter activities. Here, we report that ORF8b seem to regulate MDA5 or RIG-I differentially as protein levels of MDA5 were significantly down-regulated while those of RIG-I were largely unperturbed. In addition, ORF8b seemed to efficiently suppress phosphorylation of IRF3 at the residues of 386 and 396 in cells transfected with RIG-I while total endogenous levels of IRF3 remained largely unchanged. Furthermore, ORF8b was able to inhibit all forms of RIG-I; full-length, RIG-I-1-734, and RIG-I-1-228, last of which contains only the CARD domains. Taken together, it is tempting to postulate that ORF8b may interfere with the CARD-CARD interactions between RIG-I and MAVS. Further detailed analysis is required to delineate the mechanisms of how ORF8b inhibits the MDA5/RIG-I receptor signaling pathway.

The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March 2020. This pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic islet ?-cell dysfunction or apoptosis and insulin's inability to dispose of glucose into cellular tissues. Diabetes is known to be one of the top pre-existing co-morbidities associated with the severity of COVID-19 along with hypertension, cardiocerebrovascular disease, advanced age, male gender, and recently obesity. This review focuses on how COVID-19 may be responsible for the accelerated development of type 2 diabetes mellitus (T2DM) as one of its acute and suspected long-term complications. These observations implicate an active role of metabolic syndrome, systemic and tissue islet renin-angiotensin-aldosterone system, redox stress, inflammation, islet fibrosis, amyloid deposition along with ?-cell dysfunction and apoptosis in those who develop T2DM. Utilizing light and electron microscopy in preclinical rodent models and human islets may help to better understand how COVID-19 accelerates islet and ?-cell injury and remodeling to result in the long-term complications of T2DM.

Infection preventive practice of using disinfectants against SARS-CoV-2 has become the new normal due to the COVID-19 pandemic Although disinfectants may not be applied directly to the human body, it remains at high risk of exposure including close skin contact on disinfected surfaces or during handling This dermal contact, on a regular basis, can induce hazardous skin reactions like irritation, inflammation, and burning in severe conditions Disinfectants are germicide chemicals that can penetrate the skin and create skin reactions that are usually regarded as irritant and allergic contact dermatitis More importantly, disinfectants can react with skin components (proteins and lipids) to facilitate their skin penetration and disrupt the skin barrier function Whereas the antimicrobial actions of disinfectants are well understood, much less is known regarding their dermatologic reactions, including but not limited to irritation and hypersensitivity We reviewed the skin reactions created by those disinfectants against SARS-CoV-2 approved by the European Chemical Agency and the United States Environmental Protection Agency

OBJECTIVE: To report the impact of the COVID-19 pandemic on the activity of nurses working on an inflammatory bowel disease (IBD) unit and to identify reasons for telehealth care and its relationship to certain characteristics. BACKGROUND: The COVID-19 pandemic had led to an increase in demand for remote care in patients with inflammatory bowel disease who require monitoring and frequent access to health services. DESIGN - METHODS: A retrospective study of all activity (in person and by phone call or email) done on the unit during the acute phase of the pandemic at a reference hospital in Spain. Numbers of activities done by nurses, reasons for telehealth care and sociodemographic and clinical data were collected. Statistical analysis was performed using frequency, chi-squared and analysis of variance tests. RESULTS: A total of 1095 activities for 561 patients who received care were reported. Among them, 1042 (95.2%) were telemedicine activities, amounting to a 47.3% increase over the prior year. COVID-19-related activities numbered 588 (59.5%). Consultations due to disease flare-up numbered 134 (13.7%), representing a 145% increase compared to 2019. Significant differences were found between reasons for using telemedicine and diagnosis, occupational status, contact week and treatment. CONCLUSION: The acute phase of the pandemic has changed the activity managed by the nursing staff on the unit. Identifying and analysing these changes has yielded valuable information to achieve more efficient management and better care quality for patients in special situations.

Radiation therapy (RT) is considered one of the cornerstone modalities of treatment for different cancer types. The preparation and delivery of RT requires a number of staff members from different disciplines within the radiation oncology department. Since the emergence of the corona virus disease 2019 (COVID-19) pandemic, RT, similar to other cancer care modalities, has been adapted to minimize patient and staff exposure without compromising the oncological outcomes. This was reflected in the dramatic practice changes that occurred in the past year to address the lockdown restrictions and fulfill the infection control requirements. RT practices differ across regions based on financial and training levels, and developing countries with limited resources have struggled to maintain radiation treatment services at a level equivalent to that in developed countries while following pandemic control guidelines. The response during the COVID-19 pandemic varied between developing countries according to the infection rate and RT technological capabilities. In this editorial, we review recently published articles addressing radiotherapy practice reports during the COVID-19 pandemic in developing countries.

Early case series suggest that about one-third of patients with COVID-19 present with neurological manifestations, including cerebrovascular disease, reported in 2%C6% of hospitalised patients. These are generally older patients with severe infection and comorbidities. Here we discuss the case of a previously fit and well 39-year-old man who presented with fever and respiratory symptoms, evolving in pneumonia with hypoxia but only requiring continuous positive airway pressure. After resolution of the respiratory disease, the patient developed focal neurology and was found to have bilateral occipital, thalamic and cerebellar infarcts. A diagnosis of COVID-19 central nervous system vasculopathy was made. He developed a florid neuropsychiatric syndrome, including paranoia, irritability, aggression and disinhibition, requiring treatment with antipsychotics and transfer to neurorehabilitation. Neuropsychometry revealed a wide range of cognitive deficits. The rapid evolution of the illness was matched by fast resolution of the neuropsychiatric picture with mild residual cognitive impairment.

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has rapidly disrupted traditional modes of operation in healthcare and education. In March 2020, institutions in the United States began to implement a range of policies to discourage direct contact and encourage social distancing. These measures have placed us in an unprecedented position where education can no longer occur at close quarters - most notably, around a multi-headed microscope - but must instead continue at a distance. This guide is intended to be a resource for pathologists and pathologists-in-training who wish to leverage technology to continue collaboration, teaching, and education in this era. The manuscript is focused mainly on anatomic pathology; however, the technologies easily lend themselves to clinical pathology education as well. Our aim is to provide curated lists of various online resources that can be used for virtual learning in pathology, provide tips and tricks, and share our personal experience with these technologies. The lists include video conferencing platforms, pathology websites, free online educational resources, including social media, and whole-slide imaging collections. We are currently living through a unique situation without a precedent or guidebook, and we hope that this guide will enable the community of pathology educators worldwide to embrace the opportunities that 21st century technology provides.

In this article, we aim to stress that the fight of COVID-19 needs clear and timely data collection plans. Without data to support decisions, we can only hope for a fortunate guess. We need synergies between different research communities, policy-makers, Official Statistics, health institutions, and private companies which may provide non-conventional source of data. After having discussed policies and data collection initiatives in several European countries, we argue that on the one hand policy decisions are often not driven by the data. On the other hand, data collection either does not occur in a timely manner or it does not enable researchers to generalise the sample results to the entire population.

The novel COVID-19, a pandemic disease, is showing an alarming spread and severity throughout the world. Globally, the community transmission of this disease is affecting people in large clusters and so it is necessary to mitigate and control them in order to minimise the social and economic consequences. This review emphasize on the origin of the coronoviral epidemics, discussion on the structural and functional basis of SARS-CoV-2, epidemiology, pathognomonic symptoms, fatality, available rapid diagnostic methods and proposed possible treatment methods for the treatment of COVID-19. The diagnostic markers with respect to genetic material of the virus based on PCR, CRISPR & APTAMER and with respect to proteins based on Antigens were discussed which provides new arena for the development. In control of a pandemic situation the policy adoption and implementation by the governments plays a major role and the policy implementation in different countries are discussed which establishes the effectiveness of the policies framed by the governments. The effectiveness of ethnic traditional medicines of various countries such as India and China in Immunity enhancement, along with their utilisation is also discussed. This review provides an insights towards the COVID-19 which helps in continuous investigation on different dimensions which could help us to understand the mysteries behind the havoc created by this invisible creature.

Perceived racism in school (i.e., a students report of being treated badly or unfairly because of their race or ethnicity) is an important yet understudied determinant of adolescent health and well-being. Knowing how perceived racism influences adolescent health can help reduce health inequities. CDCs 2021 Adolescent Behaviors and Experiences Survey (ABES), an online survey of a probability-based, nationally representative sample of U.S. public- and private-school students in grades 9C12 (N = 7,705), was conducted during JanuaryCJune 2021 to assess student behaviors during the COVID-19 pandemic. CDC analyzed data from ABES to measure perceived racism and the extent to which perceptions of racism are associated with demographic, mental health, and behavioral characteristics. Mental health and behavioral characteristics analyzed included mental health status; virtual connection with others outside of school; serious difficulty concentrating, remembering, or making decisions; and feeling close to persons at school. Demographic characteristics analyzed included sex, race and ethnicity, and grade. Prevalence of perceived racism and associations between perceived racism and demographic, mental health, and behavioral characteristics are reported overall and stratified by race and ethnicity. Approximately one third (35.6%) of U.S. high school students reported perceived racism. Perceived racism was highest among Asian (63.9%), Black (55.2%), and multiracial students (54.5%). Students who reported perceived racism had higher prevalences of poor mental health (38.1%); difficulty concentrating, remembering, or making decisions (44.1%); and not feeling close to persons at school (40.7%). Perceived racism was higher among those students who reported poor mental health than those who did not report poor mental health during the pandemic among Asian (67.9% versus 40.5%), Black (62.1% versus 38.5%), Hispanic (45.7% and 22.9%), and White students (24.5% versus 12.7%). A better understanding of how negative health outcomes are associated with student experiences of racism can guide training for staff and students to promote cultural awareness and antiracist and inclusivity interventions, which are critical for promoting safe school environments for all students.

Student's t test is valid for statistical inference under the normality assumption or asymptotically. By contrast, although the bootstrap t test was proposed in 1993, it is seldom adopted in medical research. We aim to demonstrate that the bootstrap t test outperforms Student's t test under normality in data. Using random data samples from normal distributions, we evaluated the testing performance, in terms of true-positive rate (TPR) and false-positive rate and diagnostic abilities, in terms of the area under the curve (AUC), of the bootstrap t test and Student's t test. We explore the AUC of both tests with varying sample size and coefficient of variation. We compare the testing outcomes using the COVID-19 serial interval (SI) data in Shenzhen and Hong Kong, China, for demonstration. With fixed TPR, the bootstrap t test maintained the equivalent accuracy in TPR, but significantly improved the true-negative rate from the Student's t test. With varying TPR, the diagnostic ability of bootstrap t test outperformed or equivalently performed as Student's t test in terms of the AUC. The equivalent performances are possible but rarely occur in practice. We find that the bootstrap t test outperforms by successfully detecting the difference in COVID-19 SI, which is defined as the time interval between consecutive transmission generations, due to sex and non-pharmaceutical interventions against the Student's t test. We demonstrated that the bootstrap t test outperforms Student's t test, and it is recommended to replace Student's t test in medical data analysis regardless of sample size.

Contact tracing is a central public health response to infectious disease outbreaks, especially in the early stages of an outbreak when specific treatments are limited. Importation of novel Coronavirus (COVID-19) from China and elsewhere into the United Kingdom highlights the need to understand the impact of contact tracing as a control measure. Using detailed survey information on social encounters coupled to predictive models, we investigate the likely efficacy of the current UK definition of a close contact (within 2 meters for 15 minutes or more) and the distribution of secondary cases that may go untraced. Taking recent estimates for COVID-19 transmission, we show that less than 1 in 5 cases will generate any subsequent untraced cases, although this comes at a high logistical burden with an average of 36.1 individuals (95th percentiles 0-182) traced per case. Changes to the definition of a close contact can reduce this burden, but with increased risk of untraced cases; we estimate that any definition where close contact requires more than 4 hours of contact is likely to lead to uncontrolled spread.

Wireless sensor networks (WSN) have been among the most prevalent wireless innovations over the years exciting new Internet of Things (IoT) applications. IoT based WSN integrated with Internet Protocol IP allows any physical objects with sensors to be connected ubiquitously and send real-time data to the server connected to the Internet gate. Security in WSN remains an ongoing research trend that falls under the IoT paradigm. A WSN node deployed in a hostile environment is likely to open security attacks such as Sybil attack due to its distributed architecture and network contention implemented in the routing protocol. In a Sybil attack, an adversary illegally advertises several false identities or a single identity that may occur at several locations called Sybil nodes. Therefore, in this paper, we give a survey of the most up-to-date assured methods to defend from the Sybil attack. The Sybil attack countermeasures includes encryption, trust, received signal indicator (RSSI), encryption and artificial intelligence. Specifically, we survey different methods, along with their advantages and disadvantages, to mitigate the Sybil attack. We discussed the lesson learned and the future avenues of study and open issues in WSN security analysis.